性别: 男
职称: 教授
电子邮件: [email protected]
导师类型: 博士生导师
学科方向:071001-植物学
       

        获得国家级高层次人才青年项目、上海市浦江人才等多个人才项目资助。主持多项国家重点研发、国家自然科学基金委、上海市科委和上海市教委项目，获得省部级自然科学一等奖(排第3)，并参与国家级一流本科课程教学。长期以来聚焦于从基因组多维度可塑性水平解析适应性表型性状和物种多样性形成的进化机制与分子基础，并从进化与合成生物学角度对挖掘的核心酶资源进行评估、优化与应用。已发表SCI论文60余篇，主要代表成果发表于Nature Genetics, Nature Communications, Molecular Plant, New Phytologist, Plant Communications和Plant Journal等期刊。具体研究内容包括以下三个方面：

        (1) 从多维度水平展开比较基因组学分析，揭示“复制与重排”和“杂交与渐渗”等进化机制，促进现存物种的基因组在DNA线性水平的重排，以及表观遗传修饰和染色质拓扑结构的重塑；

        (2) 从生境适应与物种分化的宏观层次，解析现存物种基因组在多维度可塑性形成的过程中，其植物防御、耐荫表型与杂草性状等关键表型形成的分子基础；

        (3) 从进化与合成生物学的角度，阐明关键表型性状形成的遗传与表观调控机制，并对核心酶资源进行评估、优化与应用。

 

代表性论文

  1. Salmon, A#, Hao, Y#, Milin, M.#, Lima, O., Cavé-Radet, A., Giraud, D., Cruaud, C., Labadie, K., Istace, B., Belse, C., Aury, J.M., Wincker, P., Li, B.*, Li, L.F.*, and Malika Ainouche*. (2025) On the way to diploidization and unexpected ploidy in the grass Sporobolus section Spartina mesopolyploids. Nature Communications 16,1997

  2. Li, L.F.#, Pusadee, T#, Wedger, M.J., Li, Y.L., Li, M.R., Lau, Y.L., Yap, S.J., Jamjod, S., Rerkasem, B., Hao, H., Song, B.K., Olsen, K.M. (2024) Porous borders at the wild-crop interface promote weed adaptation in Southeast Asia. Nature Communications 15, 1182 

  3. Hao, Y., Wang, X.F., Guo, Y.L., Li, T.Y., Yang, J., Ainouche, M.L., Salmon, A., Ju, R.T., Wu, J.H.*, Li, L.F.*, and Li, B.* (2024) Genomic and phenotypic signatures provide insights into the wide adaptation of a global plant invader. Plant Communications 5, 100820

  4. Wang, X.F., Zhang, Y.X., Niu, Y.Q., Sha, Y., Wang, Z.H., Zhang, Z.B., Yang, J., Liu, B.* and Li, L.F.*. (2023) Post‐hybridization introgression and natural selection promoted genomic divergence of Aegilops speltoides and the four S‐genome diploid species. The Plant Journal 115, 1500-1513

  5. Wang, Z.H., Wang, X.F., Lu, T.Y., Li, M.R., Jiang, P., Zhao, J., Liu, S.T., Fu, X.Q., Wendel, J.F., Van de Peer*, Liu, B*, and Li, L.F.*. (2022) Reshuffling of the ancestral core-eudicot genome and its role in shaping epigenetic modification in extant Panax. Nature Communications 13, 1902.

  6. Li, L.F.*,#, Zhang, Z.B#, Wang, Z.H., Li, N., Sha, Y., Wang, X.F., Ding, N., Li, Y., Zhao, J., Wu, Y., Gong, L., Mafessoni, F., Levy, A.A.*, and Liu, B*. (2022) Genome sequences of the five Sitopsis species of Aegilops and the origin of polyploid wheat B-subgenome. Molecular Plant 15(3): 1-16. 

  7. Li, M.R., Ding, N., Lu, T., Zhao, J., Wang, Z.H., Jiang, P., Liu, S.T., Wang, X.F., Liu, B.*, and Li, L.F.* (2021) Evolutionary contribution of duplicated genes to genome evolution in the ginseng species complex. Genome Biology and Evolution 13: evab051.

  8. Li, L.F., Cushman, S.A., He, Y.X., and Li, Y.* (2020) Genome sequencing and population genomics modeling provide insights into the local adaptation of weeping forsythia. Horticulture Research 7:130.

  9. Li, M.R., Wang, H.Y., Ding, N., Lu, T., Huang, Y.C., Xiao, H.X., Liu, B. and Li, L.F.*. (2019) Rapid diverence followed by adaptation to contrasting ecological niches of two closely related columbine species Aquilegia japonica and A. oxysepala. Genome Biology and Evolution 11:919-930.

  10. Li, L.F., Li Y.L., Jia Y.L., Caicedo A.L.*, and Olsen K.M.* (2017) Signatures of adaptation in the weedy rice genome. Nature Genetics 49: 811-814.

  11. Li, M.R., Shi, F.X., Li, Y.L., Jiang, P., Jiao, L.L., Liu, B.*, and Li, L.F.*. (2017). Genome-wide variation patterns uncover the origin and selection in cultivated ginseng (Panax ginseng Meyer). Genome Biology and Evolution 9:2159-2169.

  12. Wang, X., Zhang, H., Li, Y., Zhang, Z., Li, L.F.*, and Liu, B*. (2016). Transcriptome asymmetry in synthetic and natural allotetraploid wheats, revealed by RNA-sequencing. New Phytologist 209: 1264-1277.

  13. Li, M.R., Shi, F.X., Zhou, Y.X., Li, Y.L., Wang, X.F., Zhang, C., Wang, X.T., Liu, B., Xiao, H.X.*, and Li, L.F.* (2015). Genetic and epigenetic diversities shed light on domestication of cultivated ginseng (Panax ginseng CA Meyer). Molecular Plant. 8: 1612-1622.

  14. Li, L.F.*, Liu, B., Olsen, K.M., and Wendel, J.F. (2015). A re-evaluation of the homoploid hybrid origin of Aegilops tauschii, the donor of the wheat D-subgenome. New Phytologist 208:4-8.

  15. Li, L.F.*,#, Wang, H.Y.#, Pang, D., Liu, Y., Liu, B., and Xiao, H.X.* (2014). Phenotypic and genetic evidence for ecological speciation of Aquilegia japonica and A. oxysepala. New Phytologist 204:1028-1040.